This newly released national strategy confronts the rising rates of opioid and non-opioid related fatal overdoses. It is focused around four priorities: primary prevention, harm reduction, evidence-based treatment, and recovery support, and guided by the principles of equity; data and evidence; coordination, collaboration, and integration; and reducing stigma. The Overdose Prevention Strategy expands the scope of the crisis response beyond opioids to include other substances that are often involved in overdoses, including stimulants such as methamphetamine and cocaine. This new strategy promotes groundbreaking research and evidence-informed methods to improve the health and safety of our communities.