Developed as part of the Strengthening Systems of Care for People with HIV and Opioid Use Disorder project, this document contains brief descriptions of federal policy and systems changes due to coronavirus 2019 (COVID-19) that relate to the HIV and substance use systems of care, along with links to websites that are frequently updated for each topic. This resource serves as a reference for state partners participating in the project, as well as a place to document policies and practices in response to COVID-19 that may have implications for long-term systems changes.