This document provides an overview of the SAMHSA State Opioid Response (SOR) Funding Opportunity Announcement (FOA) TI-20-012 for fiscal year (FY) 2020, with a specific focus on incorporating strategies to address HIV/infectious diseases, harm reduction, and stimulant use. State Ryan White HIV/AIDS Program (RWHAP) Part B recipients may find this information helpful as they collaborate with behavioral health/substance use agencies/departments and develop their SOR applications.